Hospital-Diagnosed Infections, Autoimmune Diseases, and Subsequent Dementia Incidence.

ABSTRACT:

Importance

Systemic inflammation has been suggested to explain reported associations between infections and dementia. Associations between autoimmune diseases and dementia also suggest a role for peripheral systemic inflammation.

Objective

To investigate the associations of infections and autoimmune diseases with subsequent dementia incidence and to explore potential shared signals presented by the immune system in the 2 conditions.

Design, setting, and participants

This nationwide, population-based, registry-based cohort study was conducted between 1978 and 2018 (40-year study period). All Danish residents born 1928 to 1953, alive and in Denmark on January 1, 1978, and at age 65 years were included. Persons with prior registered dementia and those with HIV infections

SUBMITTER: Janbek J 

PROVIDER: S-EPMC10485730 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature