Molecular profiling of allergen-antibody IgE might decide about the efficacy of allergen immunotherapy in a patient with atopic dermatitis and allergy to house dust mites.

ABSTRACT:

Introduction

Allergen immunotherapy (AIT) has no clear recommendation for atopic dermatitis (AD).

Aim

To evaluate the effect of AIT on house dust mites (HDM) in AD patients sensitised to HDM with different baseline molecular profiles of antigens.

Material and methods

In this placebo-controlled study, 61 patients with moderate-to-severe AD allergy symptoms and HDM allergy were included. They received a 12 months' AIT with the use of HDM allergen extract or placebo. The authors adopted their AD improvement criterion after 1 year of AIT as a reduction of all examined indicators by at least 50% from the baseline for %BSA, TMS, and EASI scores. Additionally, the influence of individual HDM molecules on the final AIT effect was analysed.

Results

Finally, from the 24

SUBMITTER: Bogacz-Piaseczynska A 

PROVIDER: S-EPMC10485758 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature