Amygdala reactivity during socioemotional processing and cortisol reactivity to a psychosocial stressor.

ABSTRACT: Threat-related amygdala reactivity and the activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis have been linked to negative psychiatric outcomes. The amygdala and HPA axis have bidirectional connections, suggesting that functional variation in one system may influence the other. However, research on the functional associations between these systems has demonstrated mixed findings, potentially due to small sample sizes and cortisol sampling and data analytic procedures that investigate only pre-post differences in cortisol rather than the specific phases of the cortisol stress response. Further, previous research has primarily utilized samples of adults of mostly European descent, limiting generalizability to those of other ethnoracial identities and ages. Therefore, studies address

SUBMITTER: Roberts AG 

PROVIDER: S-EPMC10485794 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature