Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites.

ABSTRACT:

Background

Malignant ascites commonly occurs in advanced or recurrent stages of epithelial ovarian cancer during peritoneal carcinomatosis and is correlated with poor prognosis. Due to its complex composition of cellular and acellular components malignant ascites creates a unique tumor microenvironment, which mediates immunosuppression and promotes progression of disease. However, the immunosuppressive mechanisms remain poorly understood.

Methods

In the present study, we explored the antitumor activity of healthy donor NK and T cells directed against ovarian cancer cells in presence of malignant ascites derived from patients with advanced or recurrent peritoneal carcinomatosis. A wide range of methods was used to study the effect of ascites on NK and T cells (FACS, ELISA, El

SUBMITTER: Hrvat A 

PROVIDER: S-EPMC10485936 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature