Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours.

ABSTRACT:

Background

Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection. While the tumour microenvironment in adults has been widely studied to delineate determinants of immune response, the immune composition of paediatric solid tumours remains relatively uncharacterized calling for investigations to identify potential immune biomarkers.

Methods

To inform immunotherapy approaches in paediatric cancers with embryonal origin, we performed an immunogenomic analysis of RNA-seq data from 925 treatment-naïve paediatric nervous system tumours (pedNST) spanning 12 cancer types from three publicly ava

SUBMITTER: Nabbi A 

PROVIDER: S-EPMC10486055 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature