Pangenome analysis of Corynebacterium striatum: insights into a neglected multidrug-resistant pathogen.

ABSTRACT:

Background

Over the past two decades, Corynebacterium striatum has been increasingly isolated from clinical cultures with most isolates showing increased antimicrobial resistance (AMR) to last resort agents. Advances in the field of pan genomics would facilitate the understanding of the clinical significance of such bacterial species previously thought to be among commensals paving the way for identifying new drug targets and control strategies.

Methods

We constructed a pan-genome using 310 genome sequences of C. striatum. Pan-genome analysis was performed using three tools including Roary, PIRATE, and PEPPAN. AMR genes and virulence factors have been studied in relation to core genome phylogeny. Genomic Islands (GIs), Integrons, and Prophage regions have been explored in de

SUBMITTER: Nageeb WM 

PROVIDER: S-EPMC10486106 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature