Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1_UK and diverse emm12 isolates, Portugal, September 2022 to May 2023.

ABSTRACT: Since autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79). Genomic sequencing (n = 55) revealed multiple genetic lineages, dominated by the M1_UK sublineage (26/55) and more diverse emm12 isolates (12/55).

SUBMITTER: Gouveia C 

PROVIDER: S-EPMC10486195 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature