Plethysmograph training: A refinement for collection of respiration data in mice.

ABSTRACT: Inhaled chemicals can harm the airways. Different effects can result in distinct changes in respiratory patterns; the type of change indicates where and how the respiratory system is affected. Furthermore, changes in respiratory patterns may be detected at much lower substance concentrations than those that cause more serious effects, such as histopathological changes. Changes in respiratory patterns can be studied experimentally by monitoring the breathing of mice placed in plethysmographs and exposing head-out to the test substance. The method is well established; however, it is not known if training mice in being restrained in the plethysmograph could increase the quality of data collection. Here we report the results of training mice to be restrained in plethysmographs for 5 consecutiv

SUBMITTER: Sorli JB 

PROVIDER: S-EPMC10486321 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature