Liver Injury and Regeneration: Current Understanding, New Approaches, and Future Perspectives.

ABSTRACT: The liver is a complex organ with the ability to regenerate itself in response to injury. However, several factors can contribute to liver damage beyond repair. Liver injury can be caused by viral infections, alcoholic liver disease, non-alcoholic steatohepatitis, and drug-induced liver injury. Understanding the cellular and molecular mechanisms involved in liver injury and regeneration is critical to developing effective therapies for liver diseases. Liver regeneration is a complex process that involves the interplay of various signaling pathways, cell types, and extracellular matrix components. The activation of quiescent hepatocytes that proliferate and restore the liver mass by upregulating genes involved in cell-cycle progression, DNA repair, and mitochondrial function; the proliferat

SUBMITTER: Hora S 

PROVIDER: S-EPMC10486351 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature