Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics.

ABSTRACT:

Rationale

The adult cardiac extracellular matrix (ECM) is largely comprised of type I collagen. In addition to serving as the primary structural support component of the cardiac ECM, type I collagen also provides an organizational platform for other ECM proteins, matricellular proteins, and signaling components that impact cellular stress sensing in vivo.

Objective

Here we investigated how the content and integrity of type I collagen affect cardiac structure function and response to injury.

Methods and results

We generated and characterized Col1a2^-/- mice using standard gene targeting. Col1a2^-/- mice were viable, although by young adulthood their hearts showed alterations in ECM mechanical properties, as well as an unanticipated act

SUBMITTER: Bowers SLK 

PROVIDER: S-EPMC10486458 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature