Unlocking Drug Resistance in Multiple Myeloma: Adipocytes as Modulators of Treatment Response.

ABSTRACT: Multiple myeloma (MM) is an incurable hematological malignancy characterized by the clonal proliferation of malignant plasma cells. Despite the development of a diverse array of targeted drug therapies over the last decade, patients often relapse and develop refractory disease due to multidrug resistance. Obesity is a growing public health threat and a risk factor for multiple myeloma, although the mechanisms by which obesity contributes to MM growth and progression have not been fully elucidated. In the present study, we evaluated whether crosstalk between adipocytes and MM cells promoted drug resistance and whether this was amplified by obesity. Human adipose-derived stem cells (ASCs) from nineteen normal (BMI = 20-25 kg/m²), overweight (25-30 kg/m²), or obese (30-3

SUBMITTER: Ochiai M 

PROVIDER: S-EPMC10486466 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature