Molecular Theranostics in Radioiodine-Refractory Differentiated Thyroid Cancer.

ABSTRACT: Differentiated thyroid cancer (DTC) is the most common subtype of thyroid cancer and has an excellent overall prognosis. However, metastatic DTC in certain cases may have a poor prognosis as it becomes radioiodine-refractory. Molecular imaging is essential for disease evaluation and further management. The most commonly used tracers are [¹⁸F]FDG and isotopes of radioiodine. Several other radiopharmaceuticals may be used as well, with different diagnostic performances. This review article aims to summarize radiopharmaceuticals used in patients with radioiodine-refractory DTC (RAI-R DTC), focusing on their different molecular pathways. Additionally, it will demonstrate possible applications of the theranostics approach to this subgroup of metastatic DTC.

SUBMITTER: Petranovic Ovcaricek P 

PROVIDER: S-EPMC10486510 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature