Expression of Stem Cell Markers in High-LET Space Radiation-Induced Intestinal Tumors in Apc^1638N/+ Mouse Intestine.

ABSTRACT: Estimation of cancer risk among astronauts planning to undertake future deep-space missions requires understanding the quantitative and qualitative differences in radiogenic cancers after low- and high-LET radiation exposures. Previously, we reported a multifold higher RBE for high-LET radiation-induced gastrointestinal (GI) tumorigenesis in Apc^1638N/+ mice. Using the same model system, i.e., Apc^1638N/+ mice, here, we report qualitative differences in the cellular phenotype of low- and high-LET radiation-induced GI tumors. Stem cell (SC) phenotypes were identified using BMI1, ALDH1, CD133, DCLK1, MSI1, and LGR5 markers in low (γ-rays)- and high (⁵⁶Fe)-LET radiation-induced and spontaneous tumors. We also assessed the expression of these marker

SUBMITTER: Kwiatkowski E 

PROVIDER: S-EPMC10486545 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature