Epithelioid Mesothelioma Patients with Very Long Survival Display Defects in DNA Repair.

ABSTRACT:

Aim

DNA repair has an important role in malignant pleural mesothelioma (MPM) tumorigenesis and progression. Prognostic/predictive biomarkers for better management of MPM patients are needed. In the present manuscript, we analyzed the expression of more than 700 genes in a cohort of MPM patients to possibly find biomarkers correlated with survival.

Methods

A total of 54 MPM patients, all with epithelioid histology, whose survival follow-up and formalin-fixed paraffin-embedded tumors were available, were included in the study. Gene expression profiles were evaluated using a Nanostring platform analyzing 760 genes involved in different cellular pathways. The percentages of proliferating tumor cells positive for RAD51 and BRCA1 foci were evaluated using an immunofluorescence ass

SUBMITTER: Ganzinelli M 

PROVIDER: S-EPMC10486625 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature