Dataset Information

Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis.

ABSTRACT: The poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duodenal juice metabolomes of benign and malignant biliary diseases. From October 2021 to January 2023, duodenal juice was obtained from 67 patients with suspected biliary diseases who required endoscopic ultrasonography and endoscopic retrograde cholangiography for diagnosis/treatment. The samples metabolomes were analyzed via nuclear magnet resonance spectroscopy using an 800-MHz spectrometer. Metabolomes of malignant and benign diseases were then compared, and multivariate analysis was performed to determine the relevant factors for malignancy/benignancy. For benignancy, no significant predictors were observed. For malignancy, acetone was a significant predictor, with higher concentrations in the malignant group than in the benign group. Regarding the receiver operating characteristic curve analysis for biliary tract carcinoma diagnosis, the predictive value of acetone in duodenal juice was comparable with serum CA19-9 levels (area under the curve: 0.7330 vs. 0.691, p = 0.697). In conclusion, duodenal juice metabolomics is a feasible method that is available for differential diagnosis in the biliary disease field.

SUBMITTER: Kishi K

PROVIDER: S-EPMC10486759 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis.

Kishi Kazuma K Kuwatani Masaki M Ohnishi Yuki Y Kumaki Yasuhiro Y Kumeta Hiroyuki H Hirata Hajime H Takishin Yunosuke Y Furukawa Ryutaro R Nagai Kosuke K Yonemura Hiroki H Nozawa Shunichiro S Sugiura Ryo R Kawakubo Kazumichi K Aizawa Tomoyasu T Sakamoto Naoya N

Cancers 20230901 17

The poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duodenal juice metabolomes of benign and malignant biliary diseases. From October 2021 to January 2023, duodenal juice was obtained from 67 patients with suspected biliary diseases who required endoscopic ultrasonography and endoscopic retrograde cholangio ...[more]

PMID: 37686644

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Dataset Information

Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis.

Publications

Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis.

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