Multi-omics Characterization of Response to PD-1 Inhibitors in Advanced Melanoma.

ABSTRACT: Immunotherapy improves the survival of patients with advanced melanoma, 40% of whom become long-term responders. However, not all patients respond to immunotherapy. Further knowledge of the processes involved in the response and resistance to immunotherapy is still needed. In this study, clinical paraffin samples from fifty-two advanced melanoma patients treated with anti-PD-1 inhibitors were assessed via high-throughput proteomics and RNA-seq. The obtained proteomics and transcriptomics data were analyzed using multi-omics network analyses based on probabilistic graphical models to identify those biological processes involved in the response to immunotherapy. Additionally, proteins related to overall survival were studied. The activity of the node formed by the proteins involved in protei

SUBMITTER: Trilla-Fuertes L 

PROVIDER: S-EPMC10486782 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature