Functional Characterization of Transforming Growth Factor-β Signaling in Dasatinib Resistance and Pre-BCR⁺ Acute Lymphoblastic Leukemia.

ABSTRACT: The multi-kinase inhibitor dasatinib has been implicated to be effective in pre-B-cell receptor (pre-BCR)-positive acute lymphoblastic leukemia (ALL) expressing the E2A-PBX1 fusion oncoprotein. The TGFβ signaling pathway is involved in a wide variety of cellular processes, including embryonic development and cell homeostasis, and it can have dual roles in cancer: suppressing tumor growth at early stages and mediating tumor progression at later stages. In this study, we identified the upregulation of the TGFβ signaling pathway in our previously generated human dasatinib-resistant pre-BCR⁺/E2A-PBX1⁺ ALL cells using global transcriptomic analysis. We confirm the upregulation of the TGFβ pathway member SMAD3 at the transcriptional and translational levels in dasatinib-res

SUBMITTER: Mostufi-Zadeh-Haghighi G 

PROVIDER: S-EPMC10486903 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature