Gut microbiota dysbiosis characterized by abnormal elevation of <i>Lactobacillus</i> in patients with immune-mediated necrotizing myopathy.

ABSTRACT:

Aim

The gut microbiota plays an important role in human health. In this study, we aimed to investigate whether and how gut microbiota communities are altered in patients with immune-mediated necrotizing myopathy (IMNM) and provide new ideas to further explore the pathogenesis of IMNM or screen for its clinical therapeutic targets in the future.

Methods

The gut microbiota collected from 19 IMNM patients and 23 healthy controls (HCs) were examined by using 16S rRNA gene sequencing. Alpha and beta-diversity analyses were applied to examine the bacterial diversity and community structure. Welch's t test was performed to identify the significantly abundant taxa of bacteria between the two groups. Spearman correlation analysis was performed to analyze the correlation between gut m

SUBMITTER: Liang X 

PROVIDER: S-EPMC10486907 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature