Vascular-related biomarkers in psychosis: a systematic review and meta-analysis.

ABSTRACT:

Background

While the molecular underpinnings of vascular dysfunction in psychosis are under active investigation, their implications remain unclear due to inconsistent and sometimes sparse observations. We conducted a comprehensive meta-analysis to critically assess the alterations of vascular-related molecules in the cerebrospinal fluid (CSF) and blood of patients with psychotic disorders compared with healthy individuals.

Methods

Databases were searched from inception to February 23, 2023. Meta-analyses were performed using a random-effects model. Meta-regression and subgroup analyses were conducted to assess the effects of clinical correlates.

Results

We identified 93 eligible studies with 30 biomarkers investigated in the CSF and/or blood. Among the biomarkers exa

SUBMITTER: Li X 

PROVIDER: S-EPMC10486913 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature