Cadmium Exposure Affects Serum Metabolites and Proteins in the Male Guizhou Black Goat.

ABSTRACT: Food safety and environmental pollution are the hotspots of general concern globally. Notably, long-term accumulation of trace toxic heavy metals, such as cadmium (Cd), in animals may endanger human health via the food chain. The mechanism of Cd toxicity in the goat, a popular farmed animal, has not been extensively investigated to date. Therefore, in this study, ten male goats (Nubian black goat × native black goat) were exposed to Cd via drinking water containing CdCl₂ (20 mg Cd·kg^-1·BW) for 30 days (five male goats per group). In this study, we used an integrated approach combining proteomics and metabolomics to profile proteins and metabolites in the serum of Cd-exposed goats. It was found that Cd exposure impacted the levels of 30 serum metabolites and 108 protei

SUBMITTER: Li Y 

PROVIDER: S-EPMC10487163 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature