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Cobalt Protoporphyrin Blocks EqHV-8 Infection via IFN-α/β Production.

ABSTRACT: Equid alphaherpesvirus type 8 (EqHV-8) is the causative agent of severe respiratory disease, abortions, and neurological syndromes in equines and has resulted in huge economic losses to the donkey industry. Currently, there exist no therapeutic molecules for controlling EqHV-8 infection. We evaluated the potential antiviral activity of cobalt protoporphyrin (CoPP) against EqHV-8 infection. Our results demonstrated that CoPP inhibited EqHV-8 infection in susceptible cells and mouse models. Furthermore, CoPP blocked the replication of EqHV-8 via HO-1 (heme oxygenase-1) mediated type I interferon (IFN) response. In conclusion, our data suggested that CoPP could serve as a novel potential molecule to develop an effective therapeutic strategy for EqHV-8 prevention and control.

SUBMITTER: Li L

PROVIDER: S-EPMC10487175 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Cobalt Protoporphyrin Blocks EqHV-8 Infection via IFN-α/β Production.

Li Liangliang L Hu Xinyao X Li Shuwen S Li Ying Y Zhao Shengmiao S Shen Fengzhen F Wang Changfa C Li Yubao Y Wang Tongtong T

Animals : an open access journal from MDPI 20230822 17

Equid alphaherpesvirus type 8 (EqHV-8) is the causative agent of severe respiratory disease, abortions, and neurological syndromes in equines and has resulted in huge economic losses to the donkey industry. Currently, there exist no therapeutic molecules for controlling EqHV-8 infection. We evaluated the potential antiviral activity of cobalt protoporphyrin (CoPP) against EqHV-8 infection. Our results demonstrated that CoPP inhibited EqHV-8 infection in susceptible cells and mouse models. Furthe ...[more]

PMID: 37684954

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