Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC10487229 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Wang Qi Q Xiong Fei F Wu Guanhua G Wang Da D Liu Wenzheng W Chen Junsheng J Qi Yongqiang Y Wang Bing B Chen Yongjun Y
Diagnostics (Basel, Switzerland) 20230826 17
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and their cofactors or regulators. SMAD proteins act as transcription factors, regulating t ...[more]