Abandoning the Isochore Theory Can Help Explain Genome Compositional Organization in Fish.

ABSTRACT: The organization of the genome nucleotide (AT/GC) composition in vertebrates remains poorly understood despite the numerous genome assemblies available. Particularly, the origin of the AT/GC heterogeneity in amniotes, in comparison to the homogeneity in anamniotes, is controversial. Recently, several exceptions to this dichotomy were confirmed in an ancient fish lineage with mammalian AT/GC heterogeneity. Hence, our current knowledge necessitates a reevaluation considering this fact and utilizing newly available data and tools. We analyzed fish genomes in silico with as low user input as possible to compare previous approaches to assessing genome composition. Our results revealed a disparity between previously used plots of GC% and histograms representing the authentic distribution of GC%

SUBMITTER: Vohnoutova M 

PROVIDER: S-EPMC10487504 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature