Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins.

ABSTRACT: The Cl^--transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to have more in common than initially suspected, as they all participate in the pathogenic process and clinical outcomes of airway and renal diseases. In the present review, we will therefore concentrate on recent findings concerning electrolyte transport in the airways and kidneys, and the role of CFTR, SLC26A9, and the anoctamins ANO1 and ANO6. Special emphasis will be placed on cystic fibrosis and asthma, as well as renal alkalosis and polycystic kidney disease. In essence, we will summarize recent evidence indicating that CFTR is the only relevant secretory Cl^- channel in airways under basal (nonstimulated) conditions and after stimulation by secretagogues. Information is provided on th

SUBMITTER: Kunzelmann K 

PROVIDER: S-EPMC10487509 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature