Population Pharmacogenomics in Croatia: Evaluating the PGx Allele Frequency and the Impact of Treatment Efficiency.

ABSTRACT:

Background

Adverse drug reactions (ADRs) are a significant cause of mortality, and pharmacogenomics (PGx) offers the potential to optimize therapeutic efficacy while minimizing ADRs. However, there is a lack of data on the Croatian population, highlighting the need for investigating the most common alleles, genotypes, and phenotypes to establish national guidelines for drug use.

Methods

A single-center retrospective cross-sectional study was performed to examine the allele, genotype, and phenotype frequencies of drug-metabolizing enzymes, receptors, and other proteins in a random sample of 522 patients from Croatia using a 28-gene PGx panel.

Results

Allele frequencies, genotypes, and phenotypes for the investigated genes were determined. No statistically significant d

SUBMITTER: Matisic V 

PROVIDER: S-EPMC10487565 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature