BAP31 Knockout in Macrophages Affects CD4⁺T Cell Activation through Upregulation of MHC Class II Molecule.

ABSTRACT: The differentiation of CD4⁺T cells is a crucial component of the immune response. The spleen and thymus, as immune organs, are closely associated with the differentiation and development of T cells. Previous studies have suggested that BAP31 may play a role in modulating T cell activation, but the specific impact of BAP31 on T cells through macrophages remains uncertain. In this study, we present evidence that BAP31 macrophage conditional knockout (BAP31-MCKO) mice display an enlarged spleen and thymus, accompanied by activated clustering and disrupted differentiation of CD4⁺T cells. In vitro co-culture studies were conducted to investigate the impact of BAP31-MCKO on the activation and differentiation of CD4⁺T cells. The examination of costimulatory molecu

SUBMITTER: Zhao B 

PROVIDER: S-EPMC10487781 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature