The Impact of Metformin on Tumor-Infiltrated Immune Cells: Preclinical and Clinical Studies.

ABSTRACT: The tumor microenvironment (TME) plays a pivotal role in the fate of cancer cells, and tumor-infiltrating immune cells have emerged as key players in shaping this complex milieu. Cancer is one of the leading causes of death in the world. The most common standard treatments for cancer are surgery, radiation therapy, and chemotherapeutic drugs. In the last decade, immunotherapy has had a potential effect on the treatment of cancer patients with poor prognoses. One of the immune therapeutic targeted approaches that shows anticancer efficacy is a type 2 diabetes medication, metformin. Beyond its glycemic control properties, studies have revealed intriguing immunomodulatory properties of metformin. Meanwhile, several studies focus on the impact of metformin on tumor-infiltrating immune cells in

SUBMITTER: Abdelmoneim M 

PROVIDER: S-EPMC10487782 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature