Molecular Relay Stations in Membrane Nanotubes: IRSp53 Involved in Actin-Based Force Generation.

ABSTRACT: Membrane nanotubes are cell protrusions that grow to tens of micrometres and functionally connect cells. Actin filaments are semi-flexible polymers, and their polymerisation provides force for the formation and growth of membrane nanotubes. The molecular bases for the provision of appropriate force through such long distances are not yet clear. Actin filament bundles are likely involved in these processes; however, even actin bundles weaken when growing over long distances, and there must be a mechanism for their regeneration along the nanotubes. We investigated the possibility of the formation of periodic molecular relay stations along membrane nanotubes by describing the interactions of actin with full-length IRSp53 protein and its N-terminal I-BAR domain. We concluded that I-BAR is invo

SUBMITTER: Madarasz T 

PROVIDER: S-EPMC10487789 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature