NANOBODY^® Molecule, a Giga Medical Tool in Nanodimensions.

ABSTRACT: Although antibodies remain the most widely used tool for biomedical research, antibody technology is not flawless. Innovative alternatives, such as Nanobody^® molecules, were developed to address the shortcomings of conventional antibodies. Nanobody^® molecules are antigen-binding variable-domain fragments derived from the heavy-chain-only antibodies of camelids (VHH) and combine the advantageous properties of small molecules and monoclonal antibodies. Nanobody^® molecules present a small size (~15 kDa, 4 nm long and 2.5 nm wide), high solubility, stability, specificity, and affinity, ease of cloning, and thermal and chemical resistance. Recombinant production in microorganisms is cost-effective, and VHH are also building blocks for multidomain constructs. The

SUBMITTER: Kunz S 

PROVIDER: S-EPMC10487883 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature