Repeated Cocaine Intake Differentially Impacts Striatal D_2/3 Receptor Availability, Psychostimulant-Induced Dopamine Release, and Trait Behavioral Markers of Drug Abuse.

ABSTRACT: Current research indicates that altered dopamine (DA) transmission in the striatum contributes to impulsivity and novelty-seeking, and it may mediate a link concerning a higher susceptibility to drug abuse. Whether increased susceptibility to drug abuse results from a hyperdopaminergic or hypodopaminergic state is still debated. Here, we simultaneously tracked changes in DA D_2/3 receptor (D_2/3R) availability and amphetamine-(AMPH)-induced DA release in relation to impulsivity and novelty-seeking prior to, and following, cocaine self-administration (SA) in Roman high- (RHA) and low- (RLA) avoidance rats. We found that high-impulsive/high novelty-seeking RHA rats exhibited lower D_2/3R availabilities and higher AMPH-induced DA release in the striatum that pred

SUBMITTER: Uruena-Mendez G 

PROVIDER: S-EPMC10487888 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature