S. epidermidis Rescues Allergic Contact Dermatitis in Sphingosine 1-Phosphate Receptor 2-Deficient Skin.

ABSTRACT: Recent studies have identified a subtype of the S1P-receptor family called sphingosine-1-phosphate receptor 2 (S1PR2), which plays a crucial role in maintaining the skin barrier. It has been observed that S1PR2 and Staphylococcus epidermidis (S. epidermidis) work together to regulate the skin barrier. However, the interaction between these two factors is still unclear. To investigate this, a study was conducted on healthy skin and allergic contact dermatitis (ACD) using 3,4-Dibutoxy-3-cyclobutene-1,2-dione (SADBE) on the ears of S1pr2^fl/fl and S1pr2^fl/flK14-Cre mice and using 1 × 10⁶ CFU of S. epidermidis to examine its effects on the skin. The results showed that in S. epidermidis-condi

SUBMITTER: Masuda-Kuroki K 

PROVIDER: S-EPMC10487941 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature