Integrative Genome-Based Survey of the SARS-CoV-2 Omicron XBB.1.16 Variant.

ABSTRACT: The XBB.1.16 SARS-CoV-2 variant, also known as Arcturus, is a recent descendant lineage of the recombinant XBB (nicknamed Gryphon). Compared to its direct progenitor, XBB.1, XBB.1.16 carries additional spike mutations in key antigenic sites, potentially conferring an ability to evade the immune response compared to other circulating lineages. In this context, we conducted a comprehensive genome-based survey to gain a detailed understanding of the evolution and potential dangers of the XBB.1.16 variant, which became dominant in late June. Genetic data indicates that the XBB.1.16 variant exhibits an evolutionary background with limited diversification, unlike dangerous lineages known for rapid changes. The evolutionary rate of XBB.1.16, which amounts to 3.95 × 10^-4 s

SUBMITTER: Scarpa F 

PROVIDER: S-EPMC10487968 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature