Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis?

ABSTRACT: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is the result of various environmental, bacterial and genetic stimuli, which culminate in the disruption of the skin's barrier function. Characterized by highly pruritic skin lesions, xerosis and an array of comorbidities among which skin infections are the most common, this condition results in both a significant loss of quality of life and in the need for life-long treatments (e.g., corticosteroids, monoclonal antibodies and regular antibiotic intake), all of which may have harmful secondary effects. This, in conjunction with AD's rising prevalence, made the development of alternative treatment strategies the focus of both the scientific community and the pharmaceutical industry. Given their potential to both manage the

SUBMITTER: Machado M 

PROVIDER: S-EPMC10488019 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature