Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers.

ABSTRACT: The main function of exocrine Meibomian glands (MGs) is to produce a lipid-rich secretion called meibum which plays a critical role in maintaining the ocular surface homeostasis of humans and most mammals. The chemical composition of meibum, and its quantity produced by MGs, largely determine whether it can fulfill its role successfully. Aging was frequently associated with the onset of various MG-related pathologies. The goal of this study was to determine how aging affects the chemical composition and quantity of meibum in mice, and identify possible molecular markers of aging. Unbiased, untargeted and targeted lipidomic evaluation of mouse MG lipids was conducted using liquid chromatography-high-resolution mass spectrometry, and the results were analyzed using Principal Component, Ortho

SUBMITTER: Butovich IA 

PROVIDER: S-EPMC10488057 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature