Closer to the Reality-Proteome Changes Evoked by Endometrial Scratching in Fertile Females.

ABSTRACT: Endometrial scratching (ES) has been widely used in assisted reproductive technology to possibly improve pregnancy rates, but its exact mechanism is still not understood or investigated, and its benefits are controversially discussed. Hypothetically, ES may trigger a local immune response, leading to an improved endometrial receptivity. So far, it has been shown that ES affects the gene expression of cytokines, growth factors, and adhesive proteins, potentially modulating inflammatory pathways and adhesion molecule expression. Our pilot study applying proteomic analysis reveals that ES probably has an impact on the proteins involved in immune response pathways and cytoskeleton formation, which could potentially increase endometrial receptivity. Specifically, proteins that are involved in t

SUBMITTER: Scheliga I 

PROVIDER: S-EPMC10488085 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature