Circulating microRNAs as Potential Biomarkers in Pancreatic Cancer-Advances and Challenges.

ABSTRACT: There is an urgent unmet need for robust and reliable biomarkers for early diagnosis, prognosis, and prediction of response to specific treatments of many aggressive and deadly cancers, such as pancreatic cancer, and liquid biopsy-based miRNA profiling has the potential for this. MiRNAs are a subset of non-coding RNAs that regulate the expression of a multitude of genes post-transcriptionally and thus are potential diagnostic, prognostic, and predictive biomarkers and have also emerged as potential therapeutics. Because miRNAs are involved in the post-transcriptional regulation of their target mRNAs via repressing gene expression, defects in miRNA biogenesis pathway and miRNA expression perturb the expression of a multitude of oncogenic or tumor-suppressive genes that are involved in the p

SUBMITTER: Seyhan AA 

PROVIDER: S-EPMC10488102 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature