In Silico Identification and Validation of Pyroptosis-Related Genes in Chlamydia Respiratory Infection.

ABSTRACT: The incidence of Chlamydia trachomatis respiratory infection is increasing, and its pathogenesis is still unclear. Pyroptosis, as a mode of inflammatory cell death, plays a vital role in the occurrence and development of Chlamydia trachomatis respiratory infection. In this study, the potential pyroptosis-related genes involved in Chlamydia trachomatis respiratory infection were identified by constructing a mouse model of C. muridarum infection combined with bioinformatics analysis. Through in-depth analysis of the RNA sequencing data, 13 differentially expressed pyroptosis-related genes were screened, including 1 downregulated gene and 12 upregulated genes. Gene ontology (GO) analysis showed that these genes mainly regulate inflammatory responses and produce IL-

SUBMITTER: Sun R 

PROVIDER: S-EPMC10488104 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature