Modeling Side Chains in the Three-Dimensional Structure of Proteins for Post-Translational Modifications.

ABSTRACT: Amino acid substitutions and post-translational modifications (PTMs) play a crucial role in many cellular processes by directly affecting the structural and dynamic features of protein interaction. Despite their importance, the understanding of protein PTMs at the structural level is still largely incomplete. The Protein Data Bank contains a relatively small number of 3D structures having post-translational modifications. Although recent years have witnessed significant progress in three-dimensional modeling (3D) of proteins using neural networks, the problem related to predicting accurate PTMs in proteins has been largely ignored. Predicting accurate 3D PTM models in proteins is closely related to another fundamental problem: predicting the correct side-chain conformations of amino acid r

SUBMITTER: Petrovskiy DV 

PROVIDER: S-EPMC10488155 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature