Inhibition of Polyamine Catabolism Reduces Cellular Senescence.

ABSTRACT: The aging of the global population has necessitated the identification of effective anti-aging technologies based on scientific evidence. Polyamines (putrescine, spermidine, and spermine) are essential for cell growth and function. Age-related reductions in polyamine levels have been shown to be associated with reduced cognitive and physical functions. We have previously found that the expression of spermine oxidase (SMOX) increases with age; however, the relationship between SMOX expression and cellular senescence remains unclear. Therefore, we investigated the relationship between increased SMOX expression and cellular senescence using human-liver-derived HepG2 cells. Intracellular spermine levels decreased and spermidine levels increased with the serial passaging of cells (aged cells),

SUBMITTER: Uemura T 

PROVIDER: S-EPMC10488189 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature