Mitochondrial Dysfunction in PCOS: Insights into Reproductive Organ Pathophysiology.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a complex, but relatively common endocrine disorder associated with chronic anovulation, hyperandrogenism, and micro-polycystic ovaries. In addition to reduced fertility, people with PCOS have a higher risk of obesity, insulin resistance, and metabolic disease, all comorbidities that are associated with mitochondrial dysfunction. This review summarizes human and animal data that report mitochondrial dysfunction and metabolic dysregulation in PCOS to better understand how mitochondria impact reproductive organ pathophysiology. This in-depth review considers all the elements regulating mitochondrial quantity and quality, from mitochondrial biogenesis under the transcriptional regulation of both the nuclear and mitochondrial genome to the ultrastructural an

SUBMITTER: Siemers KM 

PROVIDER: S-EPMC10488260 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature