Impact of Developmental Changes of GABA_A Receptors on Interneuron-NG2 Glia Transmission in the Hippocampus.

ABSTRACT: NG2 glia receive synaptic input from neurons, but the functional impact of this glial innervation is not well understood. In the developing cerebellum and somatosensory cortex the GABAergic input might regulate NG2 glia differentiation and myelination, and a switch from synaptic to extrasynaptic neuron-glia signaling was reported in the latter region. Myelination in the hippocampus is sparse, and most NG2 glia retain their phenotype throughout adulthood, raising the question of the properties and function of neuron-NG2 glia synapses in that brain region. Here, we compared spontaneous and evoked GABA_A receptor-mediated currents of NG2 glia in juvenile and adult hippocampi of mice of either sex and assessed the mode of interneuron-glial signaling changes during development. With p

SUBMITTER: Patt L 

PROVIDER: S-EPMC10488269 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature