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Efficient Reductions of Dimethylhydrazones using Preformed Primary Amine Boranes.

ABSTRACT: A convenient method for the reduction of N,N-dimethylhydrazones using amine borane complexes generated in situ is described. It was found that primary amine borane complexes performed exceedingly well at reducing N,N-dimethylhydrazones in as little as 1.1 equivalents, furnishing the corresponding air-sensitive hydrazine products in excellent yields.

SUBMITTER: Frabitore C

PROVIDER: S-EPMC10488297 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Efficient Reductions of Dimethylhydrazones using Preformed Primary Amine Boranes.

Frabitore Christian C Lepeule Jerome J Towey Bradley B Livinghouse Tom T Robinson William C WC

Synthetic communications 20211207 2

A convenient method for the reduction of N,N-dimethylhydrazones using amine borane complexes generated in situ is described. It was found that primary amine borane complexes performed exceedingly well at reducing N,N-dimethylhydrazones in as little as 1.1 equivalents, furnishing the corresponding air-sensitive hydrazine products in excellent yields. ...[more]

PMID: 37693841

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