Sensitive Detection of Various Forms of Hydrogen Sulfide via Highly Selective Naphthalimide-Based Fluorescent Probe.

ABSTRACT: Hydrogen sulfide (H₂S) is an important gasotransmitter, but only a few methods are available for real-time detection. Fluorescent probes are attractive tools for biological applications because of their high sensitivity, convenience, rapid implementation, noninvasive monitoring capability, and simplicity in fluorescent imaging of living cells and tissues. Herein, we report on a pro-fluorescent probe, NAP-Py-N₃ based on naphthalimide derivative, which was found to show high selectivity toward H₂S over various other analytes, including biothiols, making it feasible to detect H₂S. After reaction with H₂S, this probe showed rapid and significant turn-on green fluorescent enhancement at 553 nm (about 54-fold, k₂ = 9.62 M^-1</

SUBMITTER: Slowinski D 

PROVIDER: S-EPMC10488666 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature