Design, Synthesis and Antifungal Activities of Novel Pyrazole Analogues Containing the Aryl Trifluoromethoxy Group.

ABSTRACT: On the basis of the three-component synthetic methodology developed by us, a total of twenty-six pyrazole compounds bearing aryl OCF₃ were designed and synthesized. Their chemical structures were characterized by ¹H and ¹³C nuclear magnetic resonance and high-resolution mass spectrometry. These compounds were evaluated systematically for antifungal activities in vitro against six plant pathogenic fungi by the mycelium growth rate method. Most of the compounds showed some activity against each of the fungi at 100 μg/mL. Compounds 1t and 1v exhibited higher activity against all the tested fungi, and 1v displayed the highest activity against F. graminearum with an EC₅₀ value of 0.0530 μM, which was comparable with commerc

SUBMITTER: Zhao T 

PROVIDER: S-EPMC10488855 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature