Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke Prevention: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Despite preventive measures, stroke rates remain high in the primary and secondary prevention settings. Factor XIa inhibition may offer a novel, safe and effective antithrombotic option for stroke prevention.

Methods

We conducted a systematic review and meta-analysis including all available randomized controlled clinical trials (RCTs) that investigated the efficacy and safety of factor XIa inhibitors versus controls in primary or secondary stroke prevention. The primary efficacy and safety outcomes of interest were symptomatic ischemic stroke (IS) and the composite of major bleeding and clinically relevant non-major bleeding.

Results

Four phase II dose-finding RCTs were included, comprising a total of 4732 patients treated with factor XIa inhibitors versu

SUBMITTER: Palaiodimou L 

PROVIDER: S-EPMC10488897 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature