Endogenous Sex Hormone Levels and Myocardial Fibrosis in Men and Postmenopausal Women.

ABSTRACT:

Background

Sex hormone (SH) imbalances have been linked to a higher risk of heart failure in both sexes. However, mechanisms that underlie this relationship remain unclear. We examined the association of baseline SH with interstitial and replacement myocardial fibrosis in the MESA (Multi-Ethnic Study of Atherosclerosis) using cardiac magnetic resonance (CMR) T1 mapping and late gadolinium enhancement (LGE).

Objectives

The purpose of this study was to assess the link between baseline sex hormone levels and myocardial fibrosis in the MESA cohort using CMR.

Methods

A total of 2,324 participants (men and postmenopausal women [PMW]) were included in the MESA with SH measured at baseline and had underwent CMR 10 years later. All analyses were stratified by sex and age. Regr

SUBMITTER: Chehab O 

PROVIDER: S-EPMC10489298 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature