Identification of a new anoikis-related gene signature for prognostic significance in head and neck squamous carcinomas.

ABSTRACT: Anoikis, a mode of programmed cell death, is essential for normal development and homeostasis in the organism and plays an important role in the onset and progression of cancers. The authors of this research sought to establish a gene signature associated with anoikis to predict therapy outcomes and patient prognosis for individuals with head and neck squamous cell carcinoma (HNSCC). Transcriptome data of anoikis-related genes (ARGs) in individuals with HNSCC were retrieved from public databases to aid in the formulation of the gene signature. A novel ARG signature was then created using a combination of the Least Absolute Shrinkage and Selection Operator regression and Cox regression analysis. The relationship between ARGs and tumor immune microenvironment in HNSCC was explored using sing

SUBMITTER: Wei Z 

PROVIDER: S-EPMC10489427 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature