Vitamin D Status, Vitamin D Receptor Polymorphisms, and the Risk of Incident Rosacea: Insights from Mendelian Randomization and Cohort Study in the UK Biobank.

ABSTRACT:

Background

Previous cross-sectional studies have failed to definitively establish a causal relationship between serum 25-hydroxyvitamin D (25OHD) concentrations and the onset of rosacea.

Objective

To investigate the potential association between serum 25OHD levels, vitamin D receptor (VDR) polymorphisms, and the risk of developing incident rosacea.

Methods

This cross-sectional population-based cohort study utilizing 370,209 individuals from the UK Biobank. Cox proportional hazard regression models and two-sample Mendelian randomization (MR) analyses were applied to explore the causative relationship between 25OHD and incident rosacea.

Results

Our findings revealed that elevated levels of serum 25OHD were inversely correlated with the risk of incident rosacea. S

SUBMITTER: Mao R 

PROVIDER: S-EPMC10489658 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature