Magnetically Controlled Hyaluronic Acid-Maghemite Nanocomposites with Embedded Doxorubicin.

ABSTRACT: The controllable delivery of drugs is a key task of pharmacology. For this purpose, a series of polymer composites was synthesized via the cross-linking of hyaluronate and a hyaluronate/polyacrylate mixture with Fe₂O₃ nanoparticles. The cross-linking imparts magnetic properties to the composites, which are more pronounced for the ternary hyaluronate/polyacrylate/γ-Fe₂O₃ composites compared with the binary hyaluronate/Fe₂O₃ composites. When dispersed in water, the composites produce microsized hydrogel particles. Circulation of the ternary microgels in an aqueous solution at a speed of 1.84 cm/s can be stopped using a permanent external magnet with a magnetic flux density of 400 T. The composite hydrogels can absorb the antit

SUBMITTER: Spiridonov V 

PROVIDER: S-EPMC10489843 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature