Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role of Cyr61 m6A.

ABSTRACT:

Background

Several epidemiological investigations demonstrated that maternal arsenic (As) exposure elevated risk of fetal growth restriction (FGR), but the mechanism remains unclear.

Objectives

This study aimed to investigate the effects of gestational As exposure on placental and fetal development and its underlying mechanism.

Methods

Dams were exposed to 0.15, 1.5, and 15mg/L NaAsO2 throughout pregnancy via drinking water. Sizes of fetuses and placentas, placental histopathology, and glycogen content were measured. Placental RNA sequencing was conducted. Human trophoblasts were exposed to NaAsO2 (2μM) to establish an in vitro model of As exposure. The mRNA stability and protein level of genes identified through RNA sequencing were measured. N6-Methyladenosine

SUBMITTER: Song YP 

PROVIDER: S-EPMC10489955 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature